MétaCan
Menu
← Back to cohort
Record W4414040494 · doi:10.1139/apnm-2025-0238

The effects of long muscle length isometric versus full range of motion isotonic training on regional quadriceps femoris hypertrophy in resistance-trained individuals

2025· article· en· W4414040494 on OpenAlexvenueno aff
Dorian Varović, Kristian Žganjer, Milo Wolf, Patroklos Androulakis‐Korakakis, Brad J. Schöenfeld, Pavle Mikulić

Bibliographic record

VenueApplied Physiology Nutrition and Metabolism · 2025
Typearticle
Languageen
FieldMedicine
TopicSports Performance and Training
Canadian institutionsnot available
Fundersnot available
KeywordsIsometric exerciseThighMuscle hypertrophyIsotonicQuadriceps femoris muscleRange of motionElectromyographyQuadriceps muscle

Abstract

fetched live from OpenAlex

This study explored the effects of isometric training at long muscle lengths (ISOM) versus full range of motion isotonic training (ISOT) on quadriceps femoris regional hypertrophy. Twenty-three healthy, resistance-trained men and women completed a 6-week, twice-per-week intervention. A within-subject study design was employed with limbs randomized to unilateral ISOM or ISOT knee extension. Muscle thickness was assessed pre- and post-intervention at proximal, middle, and distal sites of the anterior thigh and lateral thigh. Data was analyzed using Bayesian linear mixed-effects models. The between-condition estimate for summed anterior thigh muscle thickness was -0.20 cm (high-density credible intervals (HDI): -0.54, 0.16), with 87% probability of direction (pd), and 75% of the posterior distribution exceeding the region of practical equivalence (ROPE). At the proximal site of the anterior thigh, between-condition estimates showed the greatest directional shift in favor of ISOM (contrast estimate: -0.11 cm (95% HDI: -0.24, 0.02)), with 82% of the posterior distribution exceeding the ROPE. Minimal to negligible changes in summed and regional lateral thigh muscle thickness were found for both conditions. Overall, ISOM and ISOT elicited similar quadriceps hypertrophy in resistance-trained individuals. Isometric training at long muscle lengths may elicit a superior hypertrophic effect in the proximal anterior thigh; however, uncertainty in the effect estimates precludes definitive conclusion in this regard and further investigation is warranted.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.005

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.018
GPT teacher head0.263
Teacher spread0.245 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes1
Has abstractyes

Explore more

Same venueApplied Physiology Nutrition and Metabolism→Same topicSports Performance and Training→French-language works237,207→