Cardiovascular outcomes and aortic growth in pregnant women with Turner syndrome: data from the European Society of Cardiology EURObservational Research Programme Registry of Pregnancy and Cardiac Disease (ROPAC) III
Bibliographic record
Abstract
BACKGROUND AND AIMS: Data on cardiovascular outcomes and aortic growth in pregnant women with Turner syndrome is limited. We examine the cardiovascular and pregnancy outcomes in these women and analyze aortic growth throughout pregnancy. METHODS: The ROPAC III is a global, prospective, observational registry that enrolled pregnancies of women pre-pregnancy known with Turner syndrome from 2018 to 2023. We compared baseline characteristics and outcomes between women at low and moderate-to-high risk of aortic events and between women with a pregnancy conceived with assisted reproductive technology (ART) and those who conceived spontaneously. Linear mixed models were used to analyze aortic growth with the examinations and aortic diameter as independent and dependent variable, respectively, and random effects were used to account for repeated measurements. RESULTS: In total, 47 pregnancies were included, of which 49% were classified as moderate-to-high risk (bicuspid aortic valve, aortic dilatation and/or hypertension), and 60% occurred after ART. No maternal mortality or dissection occurred during or after pregnancy. Hypertensive disorders occurred in 26%. No differences in pregnancy outcomes were found when comparing the risk groups, but women who conceived after ART were delivered by Cesarean section more often (65% vs 42%; p=0.011) and had earlier deliveries (38 vs. 39 weeks; p=0.010) compared to women with a spontaneous conception. We observed a significant aortic growth at the sinus of Valsalva during pregnancy, however, aortic diameters during a median follow-up of seven months were not different from pre-pregnancy diameters. CONCLUSIONS: Pregnancy outcomes in women known with Turner syndrome are better than reported before. While aortic dilatation may occur during pregnancy, it appears reversible postpartum. Attention for hypertension remains warranted.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".