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Record W4414082529 · doi:10.1111/acer.70147

Internalizing symptoms are indirectly associated with simultaneous alcohol and cannabis use through specific motives for simultaneous use: A longitudinal study of young adults

2025· article· en· W4414082529 on OpenAlexafffund
Jeffrey D. Wardell, Kyra N. Farrelly, Annabelle Moore, Nicolle Fox, Sophie G. Coelho, John Cunningham, Roisin M. O’Connor, Christian S. Hendershot

Bibliographic record

VenueAlcohol Clinical and Experimental Research · 2025
Typearticle
Languageen
FieldMedicine
TopicSubstance Abuse Treatment and Outcomes
Canadian institutionsConcordia UniversityYork UniversityUniversity of TorontoCentre for Addiction and Mental Health
FundersCanadian Institutes of Health Research
KeywordsYoung adultLongitudinal studyCannabisPsychological interventionHarmLongitudinal dataAlcohol

Abstract

fetched live from OpenAlex

BACKGROUND: This study examined motivational pathways between internalizing symptoms (i.e., depression, anxiety, stress) and simultaneous alcohol and cannabis use among young adults. METHODS: Participants (N = 151; 64% female, Mean age = 22.07) completed baseline questionnaires assessing internalizing symptoms and simultaneous use motives, and then reported their alcohol and cannabis use each day for 21 days. Participants repeated these procedures again 6 months and 12 months postbaseline. Daily survey responses were used to calculate the number of simultaneous use days involving heavy drinking (4 or more drinks for females; 5 or more drinks for males) and light drinking at each wave for each participant. The total number of negative consequences reported across all simultaneous use days was also calculated for each participant at each wave. RESULTS: Multilevel mediation analyses revealed that within-person increases in internalizing symptoms (a latent factor consisting of depression, anxiety, and stress indicators) at a given wave were indirectly associated with (a) a greater number of heavy drinking simultaneous use days (controlling for number of cannabis-only days and heavy drinking alcohol-only days) and (b) greater negative consequences on simultaneous use days (controlling for negative consequences on cannabis-only and alcohol-only days). These within-person associations were mediated by increases in positive (i.e., reward/enhancement) motives for simultaneous use. At the between-person level, greater average internalizing symptoms (aggregated across waves) were indirectly associated with more light drinking simultaneous use days via coping motives, and with fewer heavy drinking simultaneous use days via conformity motives (controlling for frequency of single substance use). CONCLUSIONS: Young adults may combine cannabis with heavy episodic drinking more frequently during periods when they experience elevations in internalizing symptoms, mediated by a desire to achieve the positive/enhancing effects of simultaneous use. Findings may inform alcohol and cannabis harm reduction interventions tailored for young adults with internalizing symptoms.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.003
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.090
Threshold uncertainty score0.922

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.003
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.192
GPT teacher head0.465
Teacher spread0.273 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2025
Admission routes2
Has abstractyes

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