Metastatic Squamous Cell Carcinoma of Prostatic Origin: Identification Through Next Generation Sequencing and Treatment With Pembrolizumab: A Case Report
Bibliographic record
Abstract
Squamous cell carcinomas (SCCs) of prostatic origin are rare, representing 0.5% to 1% of all prostate carcinomas. They may be present at the diagnosis but are often discovered as a transformation of an adenocarcinoma previously treated with radiotherapy or androgen deprivation therapy. The few cases described in the literature indicate an aggressive evolution, with a median survival around 14 months. This case describes a 60-year-old man who initially had metastatic adenocarcinoma of prostatic origin that evolved toward a SCC. He was treated with chemotherapy followed by pembrolizumab for maintenance. The patient maintained a response for more than 2 years and died shortly after progression of his initial adenocarcinoma. The prostatic origin of the carcinoma was identified through next generation sequencing (NGS), a technology used for the rapid and throughout sequencing of the genome. Although there was a suspicion of transformation to SCC, the origin remained unclear until the NGS provided supporting evidence.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".