INTRAOPERATIVE NEUROPLASTICITY: ROLE OF ANESTHETICS IN POSTOPERATIVE COGNITIVE DYSFUNCTION ( POCD) IN YOUNG ADULT
Bibliographic record
Abstract
Background: Postoperative cognitive dysfunction (POCD) is predominantly studied in elderly populations,with limited focus on young adults. This trial investigates the impact of anesthetic techniques (propofol TIVA vs. sevoflurane) on POCD incidence in non-geriatric adults,emphasizing NMDA receptor modulation and neuroinflammation. Methods:In a double-blind randomized trial,20 ASA I-II patients (18–40 years) undergoing elective non-cardiac surgery (>2 hours) were allocated to propofol TIVA (n=10) or sevoflurane (n=10). Cognitive function was assessed preoperatively and at 24h,72h,and 7 days postoperatively using the Montreal Cognitive Assessment (MoCA) and Trail Making Test (TMT-A/B). Serum IL-6 and TNF- levels quantified neuroinflammation. Results: Sevoflurane correlated with higher POCD incidence at 24h (40% vs. 10%, p=0.04) and greater MoCA decline ( MoCA: 2.4±0.8 vs. 0.9±0.6; p<0.001). TMT-B completion time worsened in sevoflurane at 24h ( +28.6±6.2s vs.+8.3±4.1s;p=0.002).Neuroinflammation markers rose significantly in sevoflurane (IL-6: +35.2±4.1 pg/mL vs. +12.1±3.2 pg/mL; p<0.001). Propofol showed faster cognitive recovery by day 7. Conclusion: Propofol TIVA demonstrates superior neuroprotection against POCD in young adults, potentially via attenuated neuroinflammation and NMDA-mediated neuroplasticity modulation
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.008 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.002 | 0.003 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.002 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".