Resting-State Functional Connectivity and Alcohol Use Disorder: A Case-Control Study
Bibliographic record
Abstract
OBJECTIVE: The authors examined differences in resting-state functional connectivity (rsFC) in the brain between nontreatment-seeking adults with alcohol use disorder (case group) and recreational drinkers without alcohol use disorder (control group) and explored behavioral and psychological mechanisms underlying these differences. METHODS: This case-control study included 140 adults (N=71 with alcohol use disorder and N=69 demographically matched control individuals) who completed a 9-minute resting-state functional MRI scan. About 45% were men, and the mean±SD age was 32.7±10.4 years. Seed-based rsFC analyses were conducted. Psychological mechanisms included alcohol-reinforcing value (assessed with the Alcohol Purchase Task), immediate reward orientation (delay-discounting task), and internalizing psychopathology (a composite of depression, anxiety, and posttraumatic stress measures). RESULTS: Significant rsFC differences were found between seed-target regions, including the inferior frontal gyrus and lingual gyrus, lingual gyrus and inferior occipital gyrus, nucleus accumbens and lingual gyrus, and supplementary motor cortex and temporal pole. Connectivity in these regions was significantly higher in the alcohol use disorder group, except for the supplementary motor cortex seed. Indirect effects of group differences in rsFC were found for alcohol-reinforcing value indicators and internalizing psychopathology but not delay discounting. CONCLUSIONS: This study provides initial evidence of diagnostically distinct rsFC patterns in alcohol use disorder, reflecting higher incentive salience for alcohol and elevated negative reinforcement motivation.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.014 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".