Vasoactive Intestinal Peptide: Another Player in Adipose Tissue Blood Flow Regulation?
Why this work is in the frame
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Bibliographic record
Abstract
ABSTRACT Objectives In healthy people, adipose tissue blood flow (ATBF) rises postprandially; however, in one third of them, this response is altered. These people are characterized by prolonged postprandial lipemia and higher cardiometabolic risk. Vasoactive intestinal peptide (VIP) is a gut neurotransmitter with a vasodilatory effect. The aim of the study was to assess the role of VIP in ATBF regulation and its postprandial blunting. Methods Plasma VIP and ATBF ( 133 Xenon washout technique) were measured during a 75 g oral glucose load in 16 healthy participants. ATBF was monitored in 12 individuals during in situ microinfusion of incremental doses of VIP (10 −7 , 10 −6 , 10 −5 mol L −1 ). Results Oral glucose induced no change in plasma VIP. Post‐glucose ATBF measures identified 7 non‐responders (peak blood flow < 50% of fasting values) and 9 responders. Compared to baseline (2.50 [1.96–3.59] mL·100 g −1 min −1 ), local microinfusion of VIP increased ATBF dose‐dependently: 2.67 [2.18–3.89]; 4.35 [3.33–4.65]; and 7.91 [6.59–9.88] mL·100 g −1 min −1 ( p < 0.0001) with a non‐significant lower response to VIP in non‐responders. Conclusions Our findings show a potent vasodilatory effect of VIP in adipose tissue and suggest that individuals with a blunted ATBF response to glucose load have a lower response. Whether the local unresponsiveness to VIP participates in this non‐responder status has to be confirmed in larger studies.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it