Bibliographic record
Abstract
Canada’s Drug Agency (CDA-AMC) recommends that Tagrisso be reimbursed by public drug plans for the treatment of patients with locally advanced, unresectable (stage III) non–small cell lung cancer (NSCLC) — a stage at which the cancer has spread to nearby areas but cannot be removed by surgery. This applies only to patients whose tumours have specific changes in the EGFR gene, such as exon 19 deletions (Ex19del) or exon 21 L858R substitutions (either alone or in combination with other EGFR mutations), and whose disease has not progressed during or following platinum-based chemoradiation therapy, provided certain conditions are met. Tagrisso should only be covered to treat adult patients with locally advanced unresectable (stage III) nonsquamous NSCLC (the most common subtype of NSCLS, which begins in gland-like cells in the lungs) with documented Ex19del or exon 21 L858R substitutions and who have not had disease progression during or following platinum-based chemoradiation therapy. Only patients who have a good performance status should be eligible for Tagrisso. Tagrisso should only be reimbursed if it is prescribed by clinicians with expertise in treating NSCLC and the cost of Tagrisso is reduced.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.030 | 0.011 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".