Effect of Volume Depletion and Intravascular Volume Overload on Ultrasonographically Derived Caudal Vena Cava Parameters in Healthy Sedated Cats
Bibliographic record
Abstract
ABSTRACT Objective To sonographically assess caudal vena cava (CVC) and focused cardiac ultrasound (FCU) parameters for volume depletion (VD) and intravascular volume overload (IVVO) in healthy cats. Design Prospective, randomized, blinded, crossover study. Setting Experimental. Animals Twenty‐nine healthy research‐purposed cats. Interventions The VD group received 2 mg/kg furosemide IV every 30–60 min over 6 h, followed by 10 mL/kg isotonic crystalloid or tetrastarch given over 10 min. The IVVO group did not receive furosemide and was administered 30 mL/kg isotonic crystalloid over 10 min. Ultrasonographic images of the CVC (subxiphoid view) and heart (right parasternal short‐axis view) were recorded and subjectively evaluated by an operator in real time from both groups at baseline (T0), after furosemide/6 h (T1), and after fluids (T2). CVC inspiratory (CVC insp ) and expiratory (CVC exp ) diameters, CVC collapsibility index (CVC CI ), left atrium‐to‐aorta ratio (LA:Ao), and left ventricular internal diameter in systole (LVIDs) and diastole (LVIDd) were measured and subjectively graded post hoc by two blinded raters (different to the operator) for CVC parameters; one blinded rater evaluated FCU parameters. Measurements and Main Results In the VD group, CVC insp ( p = 0.004), CVC exp ( p = 0.008), LVIDs ( p < 0.001), and LVIDd ( p < 0.001) were smaller after administration of furosemide. In the IVVO group, CVC insp ( p = 0.02), CVC exp ( p = 0.04), LVIDs ( p < 0.001), and LVIDd ( p = 0.001) were larger after fluid administration. The LA:Ao ratio was not different in any group at any time. Intrarater and interrater reliability were moderate to poor. Subjective CVC and FCU assessments were consistent with objective measurements. Conclusions Experimentally induced VD and volume overload result in sonographically detectable changes in the CVC insp and CVC exp diameters and LVIDs and LVIDd of cats, suggesting the assessment of these parameters may have value in the clinical setting.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".