Biohybrid Living Material with Antibacterial and Regenerating Properties Based on Probiotic Bacteria Stress Metabolism Modulation
Bibliographic record
Abstract
Wound healing is an intricate process that involves various biochemical pathways at each stage of tissue regeneration. Wound therapy is a series of distinct treatment stages that has a limited efficacy if wounds are of complex etiologies. A modern approach to this problem may be the development of bifunctional adaptive biohybrid systems that can concurrently affect pathogens' growth, inflammation, and tissue regeneration. We have developed biohybrid living material with antibacterial and regenerating properties based on induced hormesis by oxidative stress onto probiotic bacteria with prolonged synthesis of hydrogen peroxide, increased antibacterial action, and regeneration of the burn wound. Material demonstrates almost complete wound healing with a wound area difference 3-4 times with natural healing in vivo burn wound model for 21 days, antibacterial activity against wound antibiotic-resistance pathogens Escherichia coli K12 and Staphylococcus aureus ATCC 29213 in 4 and 5-fold, respectively in co-cultivation model, and has no toxicity to human skin fibroblasts and β-hemolysis in the in vitro model. Our findings promise the improving tissue regeneration of burn wounds, therapy against antibiotic-resistance pathogens by eliminating antibiotics, and other classical bactericides.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".