MétaCan
Menu
← Back to cohort
Record W4414379014 · doi:10.1101/2025.09.19.25335951

Functional impact of long COVID among healthcare workers with comorbidities in Quebec, Canada

2025· preprint· en· W4414379014 on OpenAlexaffabout
Sabine Isangwe, Denis Talbot, Marie‐France Coutu, Elisabeth Canitrot, Simon Décary, Emilia Liana Falcone, Moussa Ouakki, Philippe Latouche, Alain Piché, Marc Simard, Marianne Balem, Gaston De Serres, Sara Carazo

Bibliographic record

VenuemedRxiv · 2025
Typepreprint
Languageen
FieldMedicine
TopicLong-Term Effects of COVID-19
Canadian institutionsUniversité de MontréalUniversité de SherbrookeInstitut National de Santé Publique du QuébecUniversité Laval
Fundersnot available
KeywordsComorbidityCoronavirus disease 2019 (COVID-19)Health careAbsenteeismChronic conditionPoisson regressionPandemicFunctional impairmentDistress

Abstract

fetched live from OpenAlex

Abstract Objectives Long COVID is a frequent post-infectious chronic condition that impacts quality of life and work performance. Whether individuals with comorbidities experience a greater functional impact of long COVID is unknown. We evaluated the functional impact of long COVID among healthcare workers (HCWs) with chronic cardiovascular diseases, chronic respiratory diseases, obesity, or a history of depression, and compared it with that of HCWs without comorbidities. Methods We conducted a cross-sectional study in Quebec, Canada. We compared self-reported long COVID cases to COVID-19-infected controls without long COVID on work ability, work functioning, health-related absenteeism, dyspnea-associated impairment, and psychological distress. We used inverse probability of exposure and robust Poisson regressions to estimate adjusted prevalence differences (aPD) and prevalence ratios. Comorbidity data were obtained from the Quebec integrated chronic disease surveillance system. Results A total of 3,754 and 8,439 HCWs with and without comorbidities, respectively, were included. Among HCWs with comorbidities, long COVID was associated with lower work ability, lower work functioning, more health-related long-term absenteeism, more dyspnea-associated impairment, and higher psychological distress (aPDs between 8% (95%CI: 5%-11%) for long-term absenteeism and 27% (95%CI: 22%-31%) for low work functioning). aPDs were greater among HCWs with comorbidities than among those without for low work ability (p=0.01 for interaction), for low work functioning (p=0.03), and for dyspnea-associated impairment (p<0.01). Conclusion Long COVID is associated with significant functional impairment among HCWs with pre-existing chronic conditions. What is already known on this topic People with comorbidities and those with long COVID both have affected work performance. What this study adds Long COVID is associated with a greater prevalence of low work ability, low work functioning, and dyspnea-associated impairment among workers with existing comorbidities than among those without. How this study might affect research, practice, or policy Public health, employers, and physicians should give particular attention to the specific needs of individuals affected by long COVID who already have comorbidities. There is a need for targeted occupational health policies to reduce the functional impact of long COVID among workers with comorbidities.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.033
Threshold uncertainty score0.000

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0010.002
Science and technology studies0.0020.001
Scholarly communication0.0010.000
Open science0.0010.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.019
GPT teacher head0.301
Teacher spread0.282 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

Explore more

Same venuemedRxiv→Same topicLong-Term Effects of COVID-19→French-language works237,207→