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Record W4414395077 · doi:10.1002/ajmg.a.64256

The International Summit on Health Benefits of Physical Fitness for People With Down Syndrome: Current Science, Gaps, Priorities, and Research Opportunities

2025· article· en· W4414395077 on OpenAlexaff
Nicolas M. Oreskovic, Brendan Aylward, Pieter‐Henk Boer, Véronique‐Aurélie Bricout, Nashwa Cheema, Amit Das, Bo Fernhall, Richard K. Fleming, Carolina Flórez, Dan Gordon, Alexa Gozdiff Spognardi, Thessa I.M. Hilgenkamp, Hampus Hillerstromm, Christopher Joyce, Don Keiller, Lois Kelly, Josh Komyerov, Andrew E. Lincoln, Sarah Mann, Lake Murray, Lauren T. Ptomey, Kieran F. Reid, Margot Rhondeau, Stephanie L. Santoro, Heidi I. Stanish, Joshua Tam, Amy Torres, Brian G. Skotko

Bibliographic record

VenueAmerican Journal of Medical Genetics Part A · 2025
Typearticle
Languageen
FieldMedicine
TopicCerebral Palsy and Movement Disorders
Canadian institutionsDown Syndrome Research Foundation
FundersNational Down Syndrome Society
KeywordsSummitPhysical fitnessDelphi methodHealth benefitsIdentification (biology)Health promotionProcess (computing)Delphi

Abstract

fetched live from OpenAlex

The summary paper reports on and highlights the scientific discussions and development process for new expert-recommended physical fitness guidelines for individuals with Down syndrome that occurred at the inaugural International Summit on Health Benefits of Physical Fitness for People with Down Syndrome (ISFDS). The Summit was a two-day event held in May 2025 at the Massachusetts General Hospital in Boston that brought together leading international scientists, clinicians, self-advocates, community services and industries, and local and national advocacy organizations to discuss the latest research, therapies, and collaborative opportunities in physical fitness for individuals with Down syndrome. Day 1 focused on the current state of the science and the identification of research gaps; Day 2 featured working groups dedicated to developing collaborations, planning future research, and creating expert clinical guidelines on physical fitness in children and adults with Down syndrome using a Delphi approach.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.050
metaresearch head score (Gemma)0.039
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.050
Threshold uncertainty score0.264

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0500.039
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0020.001
Science and technology studies0.0040.003
Scholarly communication0.0080.004
Open science0.0020.010
Research integrity0.0080.013
Insufficient payload (model declined to judge)0.0080.003

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.064
GPT teacher head0.398
Teacher spread0.334 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes1
Has abstractyes

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