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Record W4414501049 · doi:10.1371/journal.pone.0332377

Association of cognitive function with frailty, nutritional status, and quality of life in older adults with mild cognitive impairment

2025· article· en· W4414501049 on OpenAlexaboutno aff
María del Mar Carcelén-Fraile, Anabel Melguizo-Garín, A Guedes, Raquel Medina-Ramírez, Sandra Denche-Gil, Agustín Aibar‐Almazán, Yolanda Castellote‐Caballero, María del Carmen Carcelén‐Fraile

Bibliographic record

VenuePLoS ONE · 2025
Typearticle
Languageen
FieldMedicine
TopicFrailty in Older Adults
Canadian institutionsnot available
Fundersnot available
KeywordsAssociation (psychology)CognitionQuality of life (healthcare)Cognitive impairmentPsychological interventionCross-sectional studyMEDLINE

Abstract

fetched live from OpenAlex

BACKGROUND: In older adulthood, mild cognitive impairment is an intermediate stage between normal aging and dementia, making its detection crucial. Therefore, this study aims to analyze the associations between cognitive function and frailty, nutritional status, and quality of life in older adults with mild cognitive impairment. METHODS: This work was conducted through a cross-sectional, analytical study involving 129 adults diagnosed with mild cognitive impairment, with a mean age of 68.07 ± 4.22. For cognitive assessment, the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Isaac Verbal Fluency Test, Trail Making Test (TMT), D2 Test of Attention (D2 Test), and Digit Symbol Substitution Test (DSST) were completed; clinical and functional status was assessed using the frailty (FRAIL), Mini Nutritional Assessment (MNA), and life quality 36-Item Short Form Survey (SF-36) questionnaires. RESULTS: Regarding overall cognitive performance, the presence of mild cognitive impairment was confirmed in the sample, as was the slowing of executive functions. Regarding selective attention, participants obtained an average of 138.30 points [SD = 4.30] in the D2 test, while the average score for processing speed measured using the DSST was 43.60 [SD = 3.50]. Regarding clinical and functional variables, the average FRAIL score was 2.26 [SD = 1.67], suggesting a high prevalence of frailty and pre-frailty; the average nutritional status was 27.91 [SD = 1.88], a range of adequate nutritional status. Finally, quality of life showed an average of 61.40 [SD = 14.87], indicating a moderate level. DISCUSSION: This study shows that frailty, nutritional status, and quality of life are closely related to mild cognitive impairment. These results reinforce the need for early and multidimensional interventions that contribute to preserving the quality of life.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.005
Threshold uncertainty score0.009

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.031
GPT teacher head0.275
Teacher spread0.244 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2025
Admission routes1
Has abstractyes

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