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Preventive capabilities of hormonal contraception: advances in the first quarter of the 21st century

2025· article· en· W4414516662 on OpenAlex
Mekan R. Orazov, V.E. Radzinsky, Evgeny D. Dolgov

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

aboutThe title or abstract carries a Canadian signal from the geographic lexicon.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Bibliographic record

VenueVoprosy ginekologii akušerstva i perinatologii · 2025
Typearticle
Languageen
FieldSocial Sciences
TopicMedical and Agricultural Research Studies
Canadian institutionsnot available
Fundersnot available
KeywordsDrospirenoneDeveloped countryFamily planningCombined oral contraceptivesHormonal contraceptionQuarter (Canadian coin)PopulationEstrogenPublic health

Abstract

fetched live from OpenAlex

Combined oral contraceptives (COCs) are still the most common method of contraception due to their convenience of use and favorable safety profile. It should be remembered that patients of advanced reproductive age constitute a special group for contraceptive counseling, since not only high contraceptive efficacy but also a number of other extra-contraceptive benefits are of extreme relevance in them. At the same time, it should be noted that COCs are not a treatment method for any diseases (their direct purpose is reliable contraception!), and their extra-contraceptive benefits are only an addition to prevention. In 2022, an innovative COC based on a unique estrogen – estetrol combined with drospirenone – was registered in the Russian Federation. This combination has a number of prospects, which are discussed in this article. Key words: hormonal contraception, combined oral contraceptives, preventive effects, estetrol, drospirenone, heavy menstrual bleeding, neuroprotection, benign mammary dysplasia

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.692
Threshold uncertainty score0.968

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.003
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.299
Teacher spread0.288 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it