Hippocampal volume moderates the association between cerebrospinal fluid growth-associated protein 43 and episodic memory performance in older adults
Bibliographic record
Abstract
This study examined the relationships between fluid and imaging biomarkers associated with memory (cerebrospinal fluid growth-associated protein 43 [CSF GAP-43] and hippocampal volume) and episodic memory performance in 586 older adults (mean age = 72.6 years, SD = 7.2) from the Alzheimer's Disease Neuroimaging Initiative who completed CSF collection, Magnetic Resonance Imaging, and neuropsychological testing. Hierarchical linear regressions assessed whether FreeSurfer-derived total hippocampal volume or hippocampal subfield volume (subiculum, presubiculum, dentate gyrus, CA1) moderated the association between GAP-43 and episodic memory performance. GAP-43 and hippocampal volume were independently associated with episodic memory performance. Greater GAP-43 was associated with lower episodic memory performance in older adults with average or below-average (-1 SD) total and subfield (subiculum, presubiculum, dentate gyrus) hippocampal volume. No associations were observed in participants with above-average (+1 SD) volume. These findings suggest that GAP-43 may serve as a biomarker correlate of episodic memory impairment in those with average or below-average hippocampal volume.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".