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Record W4414606428 · doi:10.1093/oncolo/oyaf326

An asynchronous electronic consent for improving consent in research among patients with cancer

2025· article· en· W4414606428 on OpenAlexafffund
Brendan J. Chia, João Paulo Solar Vasconcelos, Daniela Hegebarth, Sophie C. Chuang, Gale Ladua, Marilyn Zhou, Howard J. Lim, Karamjit Gill, Carl Brown, Renata D’Alpino Peixoto, Karen Gelmon, Jonathan M. Loree

Bibliographic record

VenueThe Oncologist · 2025
Typearticle
Languageen
FieldMedicine
TopicEthics in Clinical Research
Canadian institutionsProvidence Health CareBC Cancer Agency
FundersCanadian Institutes of Health ResearchBC Cancer Foundation
KeywordsCancerInformed consentComprehensionAsynchronous communicationWork (physics)MEDLINE

Abstract

fetched live from OpenAlex

BACKGROUND: Informed consent is essential to ensuring ethical conduct of clinical research in oncology, but can be challenging and time-consuming to implement. Electronic consenting (e-consent) may address these issues, but acceptability of e-consent among patients with cancer must be assessed. METHODS: An asynchronous preliminary e-consent was developed for a prospective circulating tumor DNA testing study for patients with colorectal/pancreatic cancer. Following e-consent, patient satisfaction was assessed in a follow-up call before full consent was obtained. Acceptability was assessed with descriptive statistics and bivariate analysis. RESULTS: Fifty-one participants completed the preliminary e-consent, 90% of which preferred electronic full consent over traditional consent. Comfort enrolling after e-consent was rated highly by 93% of participants. Additionally, 80% of participants indicated that a follow-up call had no impact on decision to enroll. CONCLUSION: These findings suggest that asynchronous e-consenting is highly acceptable among oncology patients but future work should assess comprehension with this approach.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.008
metaresearch head score (Gemma)0.011
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Research integrity
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.116
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0080.011
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.002
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.002
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.440
GPT teacher head0.619
Teacher spread0.179 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

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