Impact of Helicobacter pylori eradication therapy on quality of life and symptoms in osteoarthritis symptoms in infected patients: A nonblinded clinical trial
Bibliographic record
Abstract
Background: Osteoarthritis (OA) is a disease whose treatment is essential due to various complications, such as pain, inflammation, and disturbance in patients’ quality of life (QOL). This study aimed to determine the effect of Helicobacter pylori eradication therapy on QOL and arthritis symptoms in patients with OA who are infected with H. pylori. Materials and Methods: In this clinical trial, 62 OA patients were categorized into two groups based on diagnostic tests: H. pylori positive and negative. The negative group received only standard OA treatment, while the positive group underwent eradication therapy in addition to standard treatment. Patients were assessed and compared before, 4 weeks, and 8 weeks after treatment using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Visual Analog Scale (VAS), and European Quality of Life Questionnaire. Data were analyzed using the SPSS software. Results: Comparison of the two groups revealed a significant reduction in physical function, joint stiffness, pain, total WOMAC, and VAS scores in the H. pylori positive group over the study period ( P < 0.05), whereas no significant changes were observed in the negative group ( P > 0.05). QOL scores improved significantly in the eradicated group ( P < 0.05). Significant improvements were seen between the eradicated and noneradicated subgroups in physical function, pain, total WOMAC, and VAS scores, with more significant improvements in the eradicated group ( P < 0.05). After the intervention, self-care and QOL scores differed significantly between the groups, with the eradicated group showing better outcomes ( P < 0.05). Conclusion: In OA patients with H. pylori infection, eradication therapy improves specific symptoms, pain, and QOL.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.004 | 0.002 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.003 | 0.002 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".