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Record W4414750656 · doi:10.1038/s41746-025-01943-1

A longitudinal analysis of declining medical safety messaging in generative AI models

2025· article· en· W4414750656 on OpenAlexaff
Ahmed Alaa, Roxana Daneshjou

Bibliographic record

Venuenpj Digital Medicine · 2025
Typearticle
Languageen
FieldSocial Sciences
TopicEthics and Social Impacts of AI
Canadian institutionsUniversity of British Columbia
Fundersnot available
KeywordsDisclaimerGenerative grammarThe InternetGenerative modelFunction (biology)Patient safetyMEDLINE

Abstract

fetched live from OpenAlex

Generative AI models, including large language models (LLMs) and vision-language models (VLMs), are increasingly used to interpret medical images and answer clinical questions. However, their responses often include inaccuracies; therefore, safety measures like medical disclaimers are critical. In this study, we evaluated the presence of disclaimers in LLM and VLM outputs across model generations released from 2022 to 2025. Responses were generated from 500 mammograms, 500 chest X-rays, 500 dermatology images, and 500 medical questions drawn from a new dataset we introduced: TIMed-Q (Top Internet Medical Question Dataset). TIMed-Q captures the most frequently searched medical queries by patients, reflecting real-world health information-seeking behavior. Disclaimer presence in LLM outputs dropped from 26.3% in 2022 to 0.97% in 2025, while VLM disclaimer rates declined from 19.6% in 2023 to 1.05%. By 2025, most models displayed no disclaimers. As models gain further capability, disclaimers must function as adaptive safeguards tailored to clinical contexts.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.012
metaresearch head score (Gemma)0.096
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: Evaluation · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.988
Threshold uncertainty score0.066

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0120.096
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0020.002
Open science0.0010.001
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0060.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.065
GPT teacher head0.441
Teacher spread0.376 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designObservational
DomainEvaluation
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations10
Published2025
Admission routes1
Has abstractyes

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