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Record W4414763249 · doi:10.1101/2025.10.01.25337054

The Brain Imaging and Neurophysiology Database: BINDing multimodal neural data into a large-scale repository

2025· preprint· en· W4414763249 on OpenAlexaff
Charlotte Maschke, Peter Hadar, Yi‐Cheng Zhang, Li Jian, Gauri Ganjoo, Andrew Hoopes, Alessandro Guazzo, Aditya Gupta, Manohar Ghanta, Bruce D. Nearing, Christine Tsien Silvers, Bharath Gunapati, Jennifer A. Kim, Shibani S. Mukerji, Adrian V. Dalca, Sahar F. Zafar, Alice Lam, Emmanuel Mignot, M. Brandon Westover

Bibliographic record

VenuemedRxiv · 2025
Typepreprint
Languageen
FieldComputer Science
TopicNeural Networks and Applications
Canadian institutionsArtificial Intelligence in Medicine (Canada)
Fundersnot available
KeywordsNeuroimagingNeurophysiologyElectroencephalographyNeuroinformaticsMedical imagingClinical neurophysiologyBrain mapping

Abstract

fetched live from OpenAlex

1 The Brain Imaging and Neurophysiology Database (BIND) represents one of the largest multi-institutional, multimodal, clinical neuroimaging repositories, comprising 1.8 million brain scans from 38,945 patients, linked to neurophysiological recordings. This comprehensive dataset addresses critical limitations in neuroimaging research by providing unprecedented scale and diversity across pathologies and health. BIND integrates de-identified data from Massachusetts General Hospital, Brigham and Women's Hospital, and Stanford University, including 1,723,699 MRI scans (1.5 Tesla, 3 Tesla, and 7 Tesla), 54,137 CT scans, 5,093 PET scans, and 526 SPECT scans, converted to standardized NIfTI format following BIDS organization. The database spans the full age spectrum (newborn to 106 years) and encompasses diverse neurological conditions alongside healthy patients. We deployed Bio-Medical Large Language Models to extract structured clinical metadata from 84,960 brain-related reports, categorizing findings into standardized pathology classifications. All imaging data are linked to previously published EEG and polysomnography recordings from the Harvard Electroencephalography Database, enabling unprecedented multimodal analyses. BIND is freely accessible for academic research through the Brain Data Science Platform ( https://bdsp.io/ ). This resource facilitates large-scale neuroimaging studies, machine learning applications, and multimodal brain research to accelerate discoveries in clinical neuroscience.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.015
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Software · Consensus signal: none
Teacher disagreement score0.011
Threshold uncertainty score0.036

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0040.015
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0070.006
Science and technology studies0.0010.001
Scholarly communication0.0030.004
Open science0.0040.006
Research integrity0.0020.002
Insufficient payload (model declined to judge)0.0110.013

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.019
GPT teacher head0.289
Teacher spread0.270 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreSoftware

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations0
Published2025
Admission routes1
Has abstractyes

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