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Record W4414798944 · doi:10.1371/journal.pone.0333699

Incidence and prevalence of neurodevelopmental disorders and disabilities among métis children in Alberta, Canada: A retrospective birth cohort study

2025· article· en· W4414798944 on OpenAlexafffundabout
Stuart Lau, Jesús Serrano-Lomelin, Matthew Hicks, Reagan Bartel, Kelsey Bradburn, Ashton James, Susan E. Crawford, Jeffrey A. Bakal, Amy Colquhoun, Anne Hicks, Manoj Kumar, Rhonda J. Rosychuk, Álvaro Osornio-Vargas, Radha Chari, Maria B. Ospina

Bibliographic record

VenuePLoS ONE · 2025
Typearticle
Languageen
FieldNursing
TopicChild Nutrition and Water Access
Canadian institutionsAlberta Health ServicesQueen's UniversityAlberta HealthGovernment of AlbertaUniversity of Alberta
FundersCanadian Institutes of Health ResearchGovernment of CanadaChildren's Hospital FoundationStollery Children’s Hospital FoundationCanada Research ChairsWomen and Children's Health Research InstituteChildren's Health Research Institute
KeywordsPoisson regressionIncidence (geometry)Retrospective cohort studyOdds ratioConfidence intervalLogistic regressionCohort studyRate ratio

Abstract

fetched live from OpenAlex

Limited research has examined the neurodevelopmental health of Métis children from a functional perspective, which is essential for culturally sensitive service planning, and policy development. This population-based retrospective birth cohort study linked provincial administrative health data of Métis and non-Métis singleton live births (2006-2016) to follow them up to 10 years of age. A random 1:4 sample of non-Métis children served as a reference group. Neurodevelopmental disorders and disabilities (NDD/D) were examined across six functional NDD/D domains. Prevalence odds ratios (pOR) with 95% confidence intervals (CI) were calculated using logistic regression models, adjusted for maternal and neonatal characteristics. Incidence rates (IR) per 1,000 person-years were estimated, and age-specific IR was modeled using longitudinal Poisson regression, adjusting for covariates. Associations between maternal and neonatal characteristics and NDD/D incidence among Métis children were examined using multivariable longitudinal Poisson regression models, with adjusted incidence rate ratios (IRR) and 95% CI reported. A total of 38,958 singleton live births were included (7,853 Métis and 31,105 non-Métis). Overall NDD/D prevalence among Métis (3.3%) and non-Métis (2.8%) children did not differ significantly after adjustment (adjusted pOR: 1.1, 95% CI: 0.9, 1.3). Learning-cognition was the most prevalent NDD/D domain. Métis children had a higher IR of NDD/D at age 2 (5.5 vs. 2.8 cases per 1,000 person-years, rate difference: 2.7 [95% CI: 0.8, 4.6]). Among Métis children, higher NDD/D incidence was associated with maternal age younger than 20 or older than 35 years, high pre-pregnancy weight, male sex, preterm birth, and congenital anomalies. While overall NDD/D prevalence was similar between Métis and non-Métis children, Métis children were more likely to be diagnosed at age 2, suggesting potential differences in early diagnosis, access to care, or underlying risk factors. A functional classification approach of neurodevelopmental health supports culturally responsive early screening and intervention strategies to address these differences.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.024
Threshold uncertainty score0.175

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0000.001
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0020.005
Science and technology studies0.0020.001
Scholarly communication0.0010.000
Open science0.0010.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.007
GPT teacher head0.211
Teacher spread0.204 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes3
Has abstractyes

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