59 No synergistic effect of supplementary lysine in late gestation and domperidone in lactation for sow milk yield.
Bibliographic record
Abstract
Abstract This project aimed to determine if providing supplementary lysine (Lys) to gilts in late-gestation and increasing prolactin concentrations in lactation can act synergistically to stimulate milk yield. On day 85 of gestation, gilts were divided in three groups: 1) fed standardized ileal digestible (SID) Lys at estimated requirement (CTL, control, 19.3 g/d SID Lys, n = 23) until day 111 of gestation, 2) fed SID Lys 34% above requirement via additional soybean meal (HILYS, 25.8 g/d SID Lys, n = 22) until day 111 of gestation, or 3) fed SID Lys 34% above requirement via additional soybean meal until day 111 of gestation and receiving domperidone throughout lactation (LYSDOMP, n = 21). The dopamine receptor antagonist domperidone [0.5 mg/kg body weight (BW)] was injected daily from the day after farrowing until weaning, as an emulsion after resuspension in canola oil, in LYSDOMP sows. During the first 4 d of lactation, LYSDOMP sows were also fed 0.5 mg/kg BW of domperidone, dissolved in 8 mL of table syrup, twice daily. The CTL and HILYS sows acted as sham-treated and received both injections and oral treatment with the vehicles. Litter size was standardized to 12 ± 1 and piglets were weighed on days 1, 7, and 22. Sow feed intake was recorded daily. Blood samples were collected on days 84 and 110 of gestation and days 1, 7, and 21 of lactation to measure prolactin, free fatty acids (FFA), and glucose (gestation only). Sow BW and backfat thickness throughout the study and feed intake in lactation were not affected by treatments (P > 0.10). Mean feed intakes across treatments were 3.99, 5.82, and 6.72 kg/d (SEM = 0.11) for weeks 1, 2, and 3 of lactation, respectively. Prolactin concentrations were increased in LYSDOMP compared with CTL and HILYS sows on days 7 and 21 (P < 0.001), being 15.0, 13.6, and 24.3 ng/mL in CTL, HILYS and LYSDOMP sows, respectively, on day 21. Treatments did not alter glucose or FFA concentrations at any timepoint (P > 0.05). Estimated milk yield (mean over lactation of 12.59, 12.73 and 12.24 ± 0.20 kg/d for CTL, HILYS and LYSDOMP sows, respectively) or piglet growth rate were not affected by treatments (P > 0.10). In conclusion, there was no synergistic effect on milk yield of increasing prolactin concentrations during lactation, via domperidone, in sows that were fed supplementary Lys in late gestation, but this was because neither treatment alone had an impact on lactation performance.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".