Functional and brain activation changes in females with subcortical subacute stroke captured through functional near infrared spectroscopy: a case series
Bibliographic record
Abstract
BACKGROUND: Females have worse functional outcomes than males after a stroke including worse standing balance, slower gait speed, and higher fatigue levels. The current understanding of stroke recovery mechanisms has not yet been able to explain why females have worse outcomes compared to males. Functional Near Infrared Spectroscopy (fNIRS) amplitude offers information on the level of cognitive effort required to perform a task, as well as the impact of rehabilitation on brain function. OBJECTIVES: The aim of this case series was to use fNIRS to provide detailed prefrontal cortex activation data on several functional lower extremity sensorimotor tasks in females admitted to a stroke inpatient rehabilitation unit. METHODS: Four female participants completed impairment, balance, gait, and fatigue measures as well as fNIRS assessments at admission and discharge from the inpatient stroke rehabilitation unit. fNIRS assessments included quiet and semi-tandem standing, and supine ankle sensorimotor tasks. RESULTS: All participants had a subcortical ischemic stroke with improvements in sensorimotor impairment (average 9-point increase on the Fugl-Meyer), balance (average 29-point increase on the Berg Balance Scale), and gait (average 0.25 m/s increase in gait speed, average 30 m increased distance on the 2-minute walk test) at discharge. Larger fNIRS amplitudes were observed at baseline which were reduced at discharge for the three supine tasks, and these changes were less evident for the two standing tasks. Two females had decreased fatigue at discharge with the other two females experiencing small increases (average 0.5-point decrease on the Fatigue Severity Scale). CONCLUSIONS: For females admitted to an inpatient stroke unit, relationships may be present with improvements on clinical scores and decreased fNIRS amplitude during supine tasks, with standing tasks generating more diverse fNIRS responses. These findings suggest that fNIRS can provide prefrontal cortex activation data in females on an inpatient stroke unit and that a standard inpatient rehabilitation program appears to have an effect on fNIRS amplitudes.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".