Genetic variants of the androgen receptor and frailty in postmenopausal women
Bibliographic record
Abstract
Epidemiological evidence suggests a relationship between frailty and age at menopause. The hormonal fluctuations associated with menopause may contribute to frailty, with androgens being prime candidates due to their anabolic properties. This study aimed to elucidate whether single nucleotide polymorphisms (SNPs) within the androgen receptor (AR) gene are associated with frailty. A cross-sectional study was conducted within the frailty sub-cohort of a population-based sample of community-dwelling postmenopausal women. Two SNPs of the AR gene, selected for their potential to modulate AR functionality, were analyzed. A multinomial ordinal regression model was applied to estimate phenotypic variance. A total of 392 women (mean age: 64.1 years) were included, with a frailty status distribution of 29.6% being frail, 38.5% prefrail, and 31.9% robust, consistent with population-based data for this age group. Neither of the selected AR gene SNPs (rs5919427 and rs2497942) showed a statistically significant association with frailty status. Age, reproductive factors (including number of deliveries and miscarriages), number of comorbidities, and body mass index were independently associated with frailty. Further research is warranted to comprehensively explore the potential role of AR gene variants in frailty susceptibility.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".