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Record W4414867467 · doi:10.1016/j.fm.2025.104945

A genomic view on lactic metabolism

2025· review· en· W4414867467 on OpenAlexafffund
Nanzhen Qiao, Michael G. Gänzle

Bibliographic record

VenueFood Microbiology · 2025
Typereview
Languageen
FieldAgricultural and Biological Sciences
TopicProbiotics and Fermented Foods
Canadian institutionsUniversity of Alberta
FundersNatural Sciences and Engineering Research Council of CanadaCanada Research Chairs
KeywordsLactic acidBacteriaFermentationMetabolismLactobacillusLactic acid fermentationFood spoilageMicrobial metabolism

Abstract

fetched live from OpenAlex

Lactic acid bacteria relate in many ways to the well-being and the economic activity of humans. Lactic acid bacteria are recognised as human pathogens but also are beneficial members of commensal microbial communities in humans and animals, and are used as probiotics. Lactic acid bacteria impact food quality and safety both as beneficial fermentation microbes and as spoilage organisms. Owing to their multi-faceted relationship to humans, the carbohydrate metabolism of lactic acid bacteria has been subject to research for more than a century. The aim of this review is to link the wealth of knowledge on lactic metabolism to the currently available genomic information on lactic acid bacteria. Homofermentative and heterofermentative lactic acid bacteria take a substantially different approach to energy generation, have different substrate preferences and thus co-exist in multiple ecological niches. Many lactic acid bacteria maintain electron transfer chains to use oxygen, nitrate or iron as terminal electron acceptors under suitable conditions. The metabolism of organic acids and diols contributes to acid resistance and support stationary-phase survival. The ecology of lactic acid bacteria also shapes metabolic preferences and several metabolic traits differentiate insect associated, vertebrate-host adapted, free living and domesticated lactic acid bacteria. Knowledge of metabolic preferences that relate to phylogeny or the adaptation to different ecological niches facilitates selection of starter cultures for conventional and novel food fermentations.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.995
Threshold uncertainty score0.712

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0000.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.036
GPT teacher head0.266
Teacher spread0.230 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations11
Published2025
Admission routes2
Has abstractyes

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