Telomerase RNA Shapes the Evolutionary Diversity of Telomerase Ribonucleoproteins (RNPs)
Bibliographic record
Abstract
Telomerase emerged in early eukaryotes as a highly specialized reverse transcriptase for maintaining chromosome integrity. The telomerase enzyme contains an integral RNA, providing the template for DNA repeat synthesis. This central telomerase RNA not only provides the template but also contributes to the enzyme's catalytic function and the biogenesis of the ribonucleoprotein. Remarkably, telomerase RNA exhibits significant diversity in sequence, structure, and biogenesis across eukaryotic lineages, a feature that sets it apart from other functional RNAs. In ciliates and plants, telomerase RNA is transcribed by RNA polymerase III, whereas in animals and fungi, it is predominantly transcribed by RNA polymerase II. These differences result in distinct pathways for RNA synthesis, maturation, and trafficking. This work highlights how the diversity in size and structure of telomerase RNAs impacts the complexity and evolution of telomerase ribonucleoproteins, spanning from unicellular eukaryotes to multicellular plants and animals, highlighting telomerase RNA's critical role in telomere biology.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".