Specific phosphorylation at Ser60 in N terminus of SlCAK1 propels bacterial cold shock protein-induced immunity in Solanaceae plants
Bibliographic record
Abstract
Plants perceive microbe-derived molecular patterns to initiate the innate immune system. The csp22 peptide, derived from bacterial cold shock protein, is uniquely recognized by cold shock protein receptor (CORE) in Solanaceae plants, yet the signaling pathway remains largely obscure. In this study, we identify that tomato csp22-activated kinase 1 (SlCAK1), belonging to the receptor-like cytoplasmic kinase subgroup VII, is essential for csp22-induced immune responses and resistance to bacterial wilt disease. SlCAK1 is rapidly recruited to the csp22 receptor complex, which results in SlCAK1 phosphorylation upon csp22 treatment. Notably, csp22-induced phosphorylation specifically occurs at the Ser60 residue in the N terminus of SlCAK1, which is critical for SlCAK1 function in immunity. Interestingly, the conservation of Ser60 is unique to Solanaceae plants. Taken together, our findings reveal the pivotal role of SlCAK1 in transducing csp22-triggered immune signaling and provide a novel activation mechanism for receptor-like cytoplasmic kinases that involves phosphorylation in the N terminus.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".