Bacterial Mini Microtubule as a Minimal Model System for Exploring Dynamic Instability Using Molecular Dynamics Simulations
Why this work is in the frame
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Bibliographic record
Abstract
Large scale computational modeling has been fruitfully applied to explore microtubules – an essential component of the cellular skeleton – for over two decades. In this paper, we describe simulations of a yet computationally unexplored minimalistic system of the bacterial mini microtubule, using the high performance resources of Lomonosov Moscow State University. We highlight similarities between the eukaryotic and bacterial microtubules at the protofilament level, the size and stability of the entire mini microtubule system and the computational benefits of using the bacterial mini microtubule as a minimal model to understand dynamic instability. Our results are discussed in the context of a bigger picture of the evolution of molecular dynamics simulations, aiming to understand microtubules, illustrating how the sophistication and scale of the computational efforts increased over the years.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it