15. Minimal clinically important differences in the Spine Oncology Study Group Outcomes Questionnaire (SOSGOQ2.0) in patients with symptomatic spinal metastases
Bibliographic record
Abstract
BACKGROUND CONTEXT: It is currently unknown what absolute change in Spine Oncology Study Group Outcomes Questionnaire (SOSGOQ2.0) represents a clinically meaningful change for a patient which causes challenges with the interpretation of the SOSGOQ2.0 total score or domain scores. PURPOSE: The aim of this study was to determine the minimally clinically important difference (MCID) for the SOSGOQ2.0 in patients with spinal metastases. STUDY DESIGN: An international multicenter prospective observational study by the AO Spine Knowledge Forum Tumor. PATIENT SAMPLE: Patients with spinal metastases who were treated with surgery and/or radiotherapy OUTCOME MEASURES: Health related quality of life (HRQOL) was evaluated using the SOSGOQ2.0 at predefined time points METHODS: The MCID values for the SOSGOQ2.0 were determined using both distribution-based as well as anchor-based methods. For the anchor-based method, the posttherapy questions of the SOSGOQ2.0 served as the anchor with response options collapsed into "improvement," "no change" and "deterioration." Spearman correlation coefficients were calculated to identify posttherapy items with a correlation of ≥0.30 with the corresponding domain scores. MCID values from the distribution-based methods were derived using the statistical characteristics of the study population and compared to the anchor-based results. RESULTS: A total of 317 patients had SOSGOQ2.0 data available at baseline and at 12 weeks posttreatment and were included in the final analyses. Anchor-based MCID values for improvement in the physical function, pain, mental health and social function domains were 10.2, 26.0, 14.4 and 17.2 respectively. Compared with the distribution-based approach, anchor-based MCIDs for improvement suggest that the patient-perceived improvement corresponds to a strong level of improvement. CONCLUSIONS: This is the first study to report MCID values for the SOSGOQ2.0 total score and domain scores. The distribution-based MCID estimates will help both clinicians as well as researchers with the interpretation of the effect of treatment for painful spinal metastases on patient reported health related quality of life (HRQOL). TRIAL REGISTRATION: Clinical trials identifier NCT01825161.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.006 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".