Prenatal and prepubertal exposures to organochlorine compounds and perfluoroalkyl substances and pubertal development at age 12: The PELAGIE cohort study
Bibliographic record
Abstract
BACKGROUND: Emerging evidence suggests that prenatal and prepubertal exposure to organochlorine compounds (OCs) and perfluoroalkyl substances (PFASs) is associated with children's reproductive health. This study examines the potential impact of these exposures on pubertal development in 12-year-old children. METHODS: Based on the French PELAGIE mother-child cohort, concentrations of OCs and PFASs were measured in cord blood (from 2003 to 2006) and in blood at age 12 (from 2016 to 2018). Medical staff assessed pubertal development (Tanner stages) at age 12, and girls self-reported age at menarche annually (ages 9-16). Associations between exposures and delayed or earlier pubertal development were analyzed using multinomial logistic and Cox regression models, adjusting for confounders, and using quantile g-computation for compound mixtures. RESULTS: Among 502 children (250 girls, 252 boys; median age: 12.8 years), prenatal PFUdA exposure in girls was associated with delayed breast development [OR (95 %CI): 2.05 (1.03,4.06)]. In boys, prenatal PFHxS exposure was associated with reduced risk of earlier gonadal development [0.47 (0.26,0.83)], and β-HCH with reduced risks of both delayed [0.66 (0.43,0.99)] and earlier [0.69 (0.48,0.97)] pubic hair development. Prepubertal exposure in girls to HCB, PCBs, and PFASs was associated with increased risk of delayed breast development [e.g. , PFOA: 2.53 (1.04,6.12)] and later age at menarche [e.g., ΣPCBs: HR 0.77 (0.61,0.97)]. In boys, prepubertal p,p'-DDE was associated with increased risk of earlier puberty [gonadal development: 1.77 (1.09,2.88); pubic hair growth: 1.56 (1.01,2.44)], while PCB-118 was associated with delayed development. Prepubertal PFASs were associated with reduced risk of earlier puberty [e.g., PFHxS-gonadal stages: 0.39 (0.20,0.75)]. In mixture analyses, no associations were observed with regards to prenatal exposure, but prepubertal exposure was associated with delayed pubertal development in girls. CONCLUSION: Prenatal and prepubertal exposure to OCs and PFASs may alter pubertal development at age 12 in girls and boys, underscoring the need for further research.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".