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A Pilot Study on Corneal Molding Speed as a Function of Oxygen Permeability of Lens Materials in Orthokeratology

2025· preprint· en· W4415044679 on OpenAlexfundno aff
Langis Michaud, Rémy Marcotte-Collard, P. Simard

Bibliographic record

VenuePreprints.org · 2025
Typepreprint
Languageen
FieldMedicine
TopicCorneal surgery and disorders
Canadian institutionsnot available
FundersCanadian Optometric Education Trust Fund
KeywordsOrthokeratologyLens (geology)Coma (optics)Oxygen permeabilityRefractive errorCorneaOptical powerMolding (decorative)

Abstract

fetched live from OpenAlex

OBJECTIVE : This study was conducted to evaluate the impact of varying lens oxygen transmis-sibility (DK) on corneal molding speed, after short-term orthokeratology (OK) lens wear. METHODS: This is a pilot prospective randomised study. Participants (aged 8–15) were seen during four visits over 3 days and were fitted with lens 1 (DK100) or lens 2 (DK180), randomly assigned. From topographic tangential differential maps, treatment zone diameter (TZD), mid-peripheral power (MPP) and width (MPW) were extracted. The total high-order aberrations (HOAs), spherical aberrations and coma were measured (5 mm diameter). RESULTS: Twelve participants were enrolled (-4.35 ± 0.89D OD; -4.18 ± 0.88 OS). At day 1, L1 corrected 60% of the refractive error, and 73% by day 3 (p=0.003), compared to 73%/97% with L2 (p=0.021). The HOAs increased significantly with both lenses after 1 and 3 days (p=0.003; p=0.036). The TZD reached 25% of the pupil area with no significant difference between the two lenses at day 1(p=0.869) or 3 (p=0.429). The MPW did not vary significantly between lenses with time. However MPP was sa-tistically significant with L2 at Day 3. (p=0.020).CONCLUSION: Using a higher DK material re-sulted in faster refractive error correction and higher mid-peripheral power generated during the first 3 days of OK lens wear.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.011

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.001
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.175
GPT teacher head0.373
Teacher spread0.197 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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