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Record W4415130459 · doi:10.48550/arxiv.2506.02075

Position: Stop Chasing the C-index when Evaluating Survival Analysis Models

2025· preprint· en· W4415130459 on OpenAlexfundno aff
Christian Marius Lillelund, Shi-ang Qi, Russell Greiner, Christian Fischer Pedersen

Bibliographic record

VenueArXiv.org · 2025
Typepreprint
Languageen
FieldComputer Science
TopicMachine Learning in Healthcare
Canadian institutionsnot available
FundersAlberta Machine Intelligence InstituteNatural Sciences and Engineering Research Council of CanadaCanadian Institute for Advanced Research
KeywordsMetric (unit)Censoring (clinical trials)Discriminative modelProbabilistic logicConcordanceSet (abstract data type)Key (lock)

Abstract

fetched live from OpenAlex

The current state of evaluation in survival analysis is plagued by the persistent use of evaluation metrics in ways that are misaligned with the stated modeling objective. In addition, many such evaluations are based on censoring assumptions that are left implicit or unjustified. This means that the reported performance can be misleading and may fail to answer the scientific or modeling question the evaluation was intended to address. In this position paper, we critically examine evaluation practices in survival analysis and highlight how censoring makes evaluation fundamentally different from standard regression or classification. We place particular focus on concordance-based measures, such as the C-index, which we show are heavily overused in the literature. To help identify appropriate metrics, we propose a set of key desiderata and introduce a double-helix ladder, in which valid evaluation requires alignment between metric and modeling assumptions. Through controlled experiments, we show that violations of this alignment can lead to misleading model comparisons. We conclude by providing practical guidance on how to evaluate a survival model.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.112
metaresearch head score (Gemma)0.467
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: Methods · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Commentary · Consensus signal: none
Teacher disagreement score0.888
Threshold uncertainty score0.594

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.1120.467
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0020.002
Bibliometrics0.0050.005
Science and technology studies0.0030.006
Scholarly communication0.0110.012
Open science0.0050.006
Research integrity0.0070.013
Insufficient payload (model declined to judge)0.0070.005

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.128
GPT teacher head0.381
Teacher spread0.253 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designTheoretical or conceptual
DomainMethods
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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Same venueArXiv.orgSame topicMachine Learning in HealthcareFrench-language works237,207