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Record W4415149012 · doi:10.1097/gox.0000000000007100

Functional Outcomes of Tongue Reconstruction After Cancer Extirpation in Different Flaps: Pedicled Versus Free Flaps: A Systematic Review

2025· review· en· W4415149012 on OpenAlexaff
Zuhera Khan, Munazza Saleem, Iqra Khan, Mohammad Fazlur Rahman

Bibliographic record

VenuePlastic & Reconstructive Surgery Global Open · 2025
Typereview
Languageen
FieldMedicine
TopicReconstructive Surgery and Microvascular Techniques
Canadian institutionsAthabasca UniversityUniversity of Toronto
Fundersnot available
KeywordsTongueCancerRetrospective cohort studyTongue NeoplasmFree flapFree flap reconstruction

Abstract

fetched live from OpenAlex

Background: Tongue reconstruction poses significant challenges, involving either pedicle or free flaps, with variations arising from the remnant native tongue tissue or complete neotongue formation. Distinct differences exist between oral tongue and posterior-tongue reconstruction, and the impact of flap nature on functional outcomes remains inconclusive. This study aimed to identify the best flap options for tongue resections based on functional outcomes, help surgeons predict posttreatment quality of life, and explore standardized methods for evaluating swallowing, tongue mobility, speech, and quality of life. Methods: A systematic search of Embase, PubMed, Cochrane Library, and Web of Science identified studies on functional outcomes after tongue reconstruction with flaps. From 782 articles, 42 were included in the review. Four independent researchers assessed bias risk using the Critical Appraisal Skills Program tool. Results: The submental flap was the most common pedicle flap, whereas free flaps such as the anterolateral thigh and radial forearm were frequently used. Functional outcomes were influenced by resection extent, reconstruction type, and postoperative radiotherapy. Neo-tongue reconstruction differed functionally from oral tongue reconstruction. Sensory or motor-innervated flaps showed better swallowing outcomes, but speech results were similar between pedicle and free flaps. Conclusions: The study's findings are limited by inconsistent data, retrospective designs, and lack of standardized methods, necessitating cautious interpretation. Free flaps consistently offer better functional outcomes for tongue reconstruction, improving over time with rehabilitation. Free flaps tailored to defect size are preferred over pedicle flaps for superior results, regardless of reconstruction site.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.008
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesMeta-epidemiology (narrow)
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Systematic review · Consensus signal: Systematic review
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.344
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.008
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0110.002
Bibliometrics0.0010.002
Science and technology studies0.0000.000
Scholarly communication0.0000.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.043
GPT teacher head0.342
Teacher spread0.299 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; both teacher heads agree on what is shown here.

Study designSystematic review
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes1
Has abstractyes

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