Chronic cerebral hypoperfusion‐induced myelin loss in normal‐appearing white matter correlates with cognitive decline: insights from moyamoya disease
Bibliographic record
Abstract
Abstract INTRODUCTION Chronic cerebral hypoperfusion (CCH)‐induced white matter hyperintensities (WMHs) are a well‐established risk factor for cognitive impairment and dementia. While animal and post mortem studies suggest that myelin loss in normal‐appearing white matter (NAWM) precedes WMHs, in vivo evidence in human brain remains limited. We aimed to investigate the associations between myelin changes in NAWM, CCH, and cognitive function in patients with moyamoya disease (MMD, a human model of CCH). METHODS We included 58 patients with MMD and 36 healthy controls, and all participants underwent 3.0T magnetic resonance imaging (MRI) with T1‐weighted, T2‐weighted, and arterial spin labeling (ASL) sequences. Myelin was assessed by the T1‐weighted/T2‐weighted ratio (rT1/T2), and cerebral blood flow (CBF) in each arterial region was measured by ASL. Cognitive function was evaluated using the Mini‐Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). RESULTS Patients exhibited decreased rT1/T2 at lower percentiles (P5 and P10) and increased rT1/T2 at higher percentiles (P75, P90, and P95) in NAWM (false discovery rate [FDR]‐corrected p < 0.005), along with reduced CBF in the region of anterior circulation (FDR‐corrected p < 0.05). Voxel‐based analysis of NAWM showed region‐specific decreases and increases in rT1/T2 in MMD. The percentile ranges (P90‐P10 and P95‐P5) of rT1/T2 showed high accuracy in differentiating patients from controls (accuracy: 88% to 90%). Multivariate analysis further revealed that in patients, both P5 and P10 of rT1/T2 were significantly associated with reduced CBF in the anterior circulation region (standardized β = 0.318, p = 0.016 and standardized β = 0.267, p = 0.043), and P5 of rT1/T2 significantly correlated with MMSE and MoCA (standardized β = 0.332, p = 0.004 and standardized β = 0.260, p = 0.011). DISCUSSION Our study provides in vivo evidence that CCH induces both myelin loss and potential plastic adaptations in NAWM, with severe myelin loss being associated with cognitive decline. Highlights MMD features CCH and cognitive decline. Decreased rT1/T2 (myelin loss) in NAWM was detected in MMD. The lower percentage of rT1/T2 correlated with CCH. The lowest percentage of rT1/T2 correlated with cognitive decline. The rT1/T2 showed high accuracy in differentiating patients from controls.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".