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Record W4415179614 · doi:10.1073/pnas.2510889122

<i>WUSCHEL-D1</i> upregulation enhances grain number by inducing formation of multiovary-producing florets in wheat

2025· article· en· W4415179614 on OpenAlexafffund
Adam Schoen, Guilherme V. Yoshikawa, Parva Kumar Sharma, Alex Mahlandt, Yi Chen, Huajin Sheng, Leon V. Kochian, Peng Gao, Daoquan Xiang, Teagen D. Quilichini, Prakash Venglat, Sheng Wang, Inderjit Singh Yadav, Robert Sablowski, Yuqi Wang, Peng Zhang, Annabel Whibley, Amy M. Hill, Yong Gu, Daniel Rodriguez-Leal, Weifeng Luo, Yiping Qi, Nathan Meier, Anmol Kajla, Gina Brown‐Guedira, Sheron Simpson, Ramey C. Youngblood, Amanda M. Hulse‐Kemp, Angus Murphy, Bikram S. Gill, Cristóbal Uauy, Raju Datla, Nidhi Rawat, Scott A. Boden, Vijay Tiwari

Bibliographic record

VenueProceedings of the National Academy of Sciences · 2025
Typearticle
Languageen
FieldAgricultural and Biological Sciences
TopicWheat and Barley Genetics and Pathology
Canadian institutionsGlobal Institute for Water SecurityNational Research Council CanadaAgriculture and Agri-Food CanadaUniversity of Saskatchewan
FundersNational Institute of Food and AgricultureU.S. Department of AgricultureYitpi FoundationAgricultural Research ServiceAustralian Research CouncilAlberta Wheat CommissionAgriculture and Agri-Food CanadaRoyal SocietyDepartment of Education and TrainingMississippi State UniversityUniversity of SydneyPunjab Agricultural UniversityNorth Carolina State University
KeywordsTILLINGComplementationInflorescenceGenePrimordiumLocus (genetics)MeristemPhenotype

Abstract

fetched live from OpenAlex

Innovative genetic improvements in food crops are needed to maintain global food security. Here, we report the map-based cloning of TaWUSCHEL-D1 ( WUS-D1 ) as the gene responsible for the multiovary phenotype in wheat, which produces three fertile ovaries and grains per floret. We generated a 14.5 Gbp chromosome-level assembly of multiovary wheat line “MOV” that shows unique structural variation in the Mov-1 physical region, resulting in widespread gene upregulation. High-resolution genetic mapping refined the locus to a 135 kbp region that contains two genes. We used nine independent deletion mutants, eight TILLING mutants, and genetic complementation of these genotypes to show that a WUSCHEL ortholog, WUS-D1 , is the causal gene of the Mov-1 locus. Expression studies showed that WUS-D1 is highly expressed during early inflorescence development in MOV, whereas the gene is inactive in wild-type wheat. The higher WUS-D1 expression is associated with the formation of larger meristems and floret primordia that are competent to produce multiple ovaries. These insights provide a foundation to manipulate floral organ numbers to enhance breeding capabilities of bread wheat.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.002

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.025
GPT teacher head0.273
Teacher spread0.248 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2025
Admission routes2
Has abstractyes

Explore more

Same venueProceedings of the National Academy of Sciences→Same topicWheat and Barley Genetics and Pathology→French-language works237,207→