Effect of small variations in hydration status due to 12-hour fasting on lower limb muscle function in middle-aged adults
Bibliographic record
Abstract
PURPOSE: Evidence on the effects of low-grade dehydration on muscle function in non-athletic middle-aged adults is scarce and inconclusive. The objective was to assess the effect of small variations in hydration status due to 12-hour overnight fasting on right-leg muscle function in middle-aged adults. METHODS: Single-group before-and-after study in volunteers aged 35-65 years. Participants were assessed at two time points: after 12 hours of absolute fasting and after breakfast and drinking 1.5 L of water. Body composition and hydration status were assessed by bioelectrical impedance analysis (BIA) and muscle function by an isokinetic test. RESULTS: Fifty-nine volunteers (47 years, 81.4% women) were recruited. Under fasting conditions, total body water, intracellular water (ICW), and extracellular water were positively correlated with knee flexion and extension strength, work, and power in men and women. The ICW to fat-free mass ratio and phase angle were positively correlated with flexion and extension strength and work in women but not men. Flexion strength and work improved significantly after water intake in women but not men. No changes in muscle function were observed in individuals younger than 45 years. In those aged 45 years or older, significant differences were observed for flexion strength (58.7 vs 61.8 N, p = 0.004), work (269.0 vs 284.0 J, p = 0.003) and power (39.5 vs 41.3 W, p = 0.018). CONCLUSION: Hydration status appears to have a role in muscle function, especially with increasing age. More studies, however, are required to better understand the influence of hydration on muscle function and the underlying mechanisms.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".