Peanut Oral Immunotherapy Using 30 and 300 mg Maintenance Doses
Bibliographic record
Abstract
Background The lowest dose of peanut oral immunotherapy (P-OIT) has not been determined. Objective To evaluate if very low dose OIT (30mg) may safely and effectively increase tolerated doses and induce immunological changes. Methods Peanut-allergic children reactive to /=443 and >/=1043mg PP were compared to Group-Avoid by DBPCFC planned at 1yr. Safety and laboratory parameters (sIgE, sIgG4) were assessed. Results We enrolled 51 children (26 (51%) male, median age 10yrs (IQR 7-13)), with initial cumulative-tolerated dose of 44mg (IQR 14-144). In Group-30mg, 15/17 completed DBPCFC (2/17 withdrawn). In Group-300mg, 12/17 completed DBPCFC (5/17 withdrawn). In Group-Avoid, 12/17 completed DBPCFC (5/17 lost to follow-up). By intention to treat, Group-30mg, 13/17 (p<<0.001 vs. Group-Avoid) tolerated >/=443 and 7/17 (p=0.007 vs. Group-Avoid) tolerated >/=1043mg PP. In the Group-300mg 10/17 (p=<0.001 vs. Group-Avoid) tolerated >/=443 and 8/17 (p=0.003 vs Group-Avoid) tolerated >/=1043mg PP. No Group-Avoid (0/17) tolerated >/=443 or >/=1043mg PP. Laboratory parameters (sIgE, sIgG4) were similar between Group-30mg and Group-300mg and significantly improved from Group-Avoid. Systemic adverse events were fewer in Group-30mg vs Group-300mg. Conclusions A 30mg maintenance dose for P-OIT significantly increases threshold over strict avoidance, clinically similarly to 300mg, and may allow for a simplified and safer OIT regimen and less treatment drop-outs. NCT03532360
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".