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Record W4415356957 · doi:10.1038/s41591-025-04030-w

Circulating tumor DNA-guided adjuvant therapy in locally advanced colon cancer: the randomized phase 2/3 DYNAMIC-III trial

2025· article· en· W4415356957 on OpenAlexafffund
Jeanne Tie, Yuxuan Wang, Jonathan M. Loree, Joshua D. Cohen, Rachel Wong, Timothy Price, Niall C. Tebbutt, Val Gebski, David Espinoza, Matthew Burge, Sam Harris, James Lynam, Belinda Lee, Margaret M. Lee, Daniel Breadner, Marlyse A. Debrincat, Siavash Foroughi, Lorraine A. Chantrill, Stephanie Lim, Sharlene Gill, Chris O’Callaghan, Janine Ptak, Natalie Silliman, Lisa Dobbyn, Maria Popoli, Chetan Bettegowda, Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Peter Gibbs, Sue‐Anne McLachlan, Madhu Singh, Theresa Hayes, Joanne Lundy, Zee Wan Wong, Geoff Chong, Ayesha Saqib, Simone Steel, Morteza Aghmesheh, Stephen Begbie, Aflah Roohullah, Philip Beale, Weng Ng, Connie I. Diakos, Ratnesh Kumar Srivastav, Sunil Rai, Matt Wong, Deme Karikios, Caroline Lum, Craig Underhill, Pirooz Poursoltan, Bhaskar Karki, Christos S. Karapetis, Adnan Khattak, Melanie Wuttke, Narayan Karanth, Mark Jeffery, Radhika Yelamanchili, Anupam Batra, Daryl Roitman, Joanna Gotfrit, Iqbal Mussawar, Shaqil Kassam, John R. Goffin, Sara Rask, Stacey Hubay, Eric X. Chen, Setareh Samimi, Samuel Martel, Urszula Zurawska, Ralph Wong, Lucas Sidéris, Patricia A. Tang, John Paul McGhie, Saroosh Arif, Shahid Ahmed, James Michael, Katharine Shim, Sam Babak, Dawn Elizabeth Armstrong, R. Burkes, Petr Kavan

Bibliographic record

VenueNature Medicine · 2025
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicCancer Genomics and Diagnostics
Canadian institutionsSinai Health SystemJewish General HospitalDr. H. Bliss Murphy Cancer CentreLakeridge HealthCredit Valley HospitalHôpital Maisonneuve-RosemontSt Joseph's Health CentreHôpital du Sacré-Cœur de MontréalGrand River HospitalPrincess Margaret Cancer CentreSaint John Regional HospitalSouthlake Regional Health CenterCambridge Memorial HospitalCancerCare ManitobaOccupational Cancer Research CentreSaskatchewan Cancer AgencyOttawa HospitalSanté MontérégieJuravinski Cancer CentreNorth York General HospitalRoyal Victoria Regional Health CentreNiagara Health System
FundersDivision of Cancer Epidemiology and Genetics, National Cancer InstituteBilli and Bernie Marcus FoundationGovernment of CanadaU.S. Department of Health and Human ServicesEastern Health FoundationLustgarten FoundationCanadian Cancer Society Research InstituteCanadian Institutes of Health ResearchConrad N. Hilton FoundationNational Health and Medical Research CouncilVirginia and D.K. Ludwig Fund for Cancer Research
KeywordsOxaliplatinColorectal cancerCirculating tumor DNAClinical endpointChemotherapyAdjuvantStage (stratigraphy)Adjuvant chemotherapyRandomized controlled trial

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.004
Threshold uncertainty score0.014

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0010.001
Open science0.0010.000
Research integrity0.0010.003
Insufficient payload (model declined to judge)0.0040.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.006
GPT teacher head0.330
Teacher spread0.324 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations39
Published2025
Admission routes2
Has abstractno

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