#3609 Cognitive functions in multymorbidity patients with atrial fibrillation depending on the presence of concomitant chronic kidney disease stages 3A, 3B and 4
Bibliographic record
Abstract
Abstract Background сognitive impairment (CI) is one of the significant public health problems. Multimorbidity patients with atrial fibrillation (AF) and chronic kidney disease (CKD) are at higher risk of developing CI, which can lead to deterioration in quality of life, difficulties in adherence to medication regimens and a higher incidence of adverse drug reactions, which determines the need to diagnose cognitive deficit in these multimorbid patients. Aims to assess the impact the stage of concomitant CKD on cognitive functions (CF) in patients with AF. Materials and methods we included 142 patients of both sexes ≥18 years old with AF in combination with CKD stages C3 and C4; 47 (33.1%) men and 95 (66.9%) women, aged 58 to 99 years (median age 84 [76; 90] years). Patients were divided into 3 groups: (i) with CKD C3a (n = 50), (ii) with CKD C3b (n = 50), (iii) with CKD C4 (n = 42). All patients underwent cognitive assessment including the Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE), Trial Making Test (parts A, B), Category Fluency, Word-List Recall and Stroop color-word conflict. Results patients with CKD C4 had a statistically significantly lower number of points on the MMSЕ, compared with patients with CKD C3a (27 [24;28] vs. 28 [26;29] points, respectively, P = 0.048). Among patients with CKD C4, there were statistically significantly fewer patients who scored ≥29 points on the MMSЕ, compared with patients with CKD C3a (8 (19%) vs. 19 (38%) patients, respectively, P = 0.047). Patients with CKD C4 reproduced a statistically significantly smaller number of words an hour after memorization than patients with CKD C3a (2 [0;3] vs. 3 [0;4] words, respectively, P = 0.017). To complete the TMT part A test, patients with CKD C4 required a statistically significantly longer time than patients with CKD C3a (89 [61;117] vs. 71 [58;91.5] seconds, respectively, P = 0.047). Conclusion the results obtained in this study indicate an adverse effect of concomitant CKD C4 on CF in patients with AF and a deterioration in CF with increasing severity of CKD.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".