The use of a neurometabolic drug for the prevention of postoperative cognitive dysfunction in elderly patients operated on the lumbosacral spine
Bibliographic record
Abstract
The objective was to evaluate the effect of perioperative use of the neurometabolic drug Cytoflavin on the dynamics of biomarkers of brain damage and the relationship of these indicators with the frequency of POCD in elderly patients who underwent surgery on the lumbosacral spine. Materials and methods . Patients were divided into two groups: patients in the first group were injected with Cytoflavin (solution for intravenous administration) in the perioperative period; in the second group, Cytoflavin was not administered. Patients were surveyed using the Montreal Cognitive Assessment Scale (MoCA) and the National Institutes of Health (NIHSS) Stroke Scale. Transcranial Dopplerography was performed to assess velocity parameters in intracranial arteries. The levels of laboratory parameters in the blood were analyzed: matrix metalloproteinase (MMP-9), brain neurotrophic factor (BDNF), neuron-specific enolase (NSE), protein S-100 (S-100), antibodies to Nmethyl-D-aspartate receptors (NMDAR), C-reactive protein (CRP), lactate, lactate dehydrogenase (LDH). The studies were conducted at several points: 1 – the day before surgery; 2 – intraoperatively at the stage of hemostasis; 3 – the next day after surgery. Results. There were no significant changes in the MoCA test results. The BDNF level decreased in the intraoperative period, returning to baseline values on the first postoperative day in both study groups. The concentration of NSE increased during surgery, returning to baseline values in the control group and decreased below baseline values in the main group. The S-100 protein increased in the control group on the first postoperative day. Fluctuations in the indicators of markers of brain damage in both study groups did not exceed the reference values. Conclusion. Perioperative use of Cytoflavin in elderly patients who underwent surgery on the lumbosacral spine had no significant effect on the dynamics of biomarkers of brain damage; no relationship between these indicators and the occurrence of POCD was found based on testing of patients on the MoCA scale.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".