OR25-08 Brain-Derived Neurotrophic Factor levels (BDNF) in Hyponatremia Correction -Subanalysis of a Randomized, Double-Blind, Placebo-Controlled, Crossover Trial
Bibliographic record
Abstract
Abstract Disclosure: J. Beck: None. E. Kustos-Toth: None. L. Seeger: None. S. Monnerat: None. C. Bathelt: None. J. Refardt: None. M. Christ-Crain: None. Background: Hyponatremia is the most common electrolyte disorder in clinical practice and is associated with cognitive impairment. We have recently shown that correction of sodium levels can improve cognitive function1. Growing evidence suggests that serum brain-derived neurotrophic factor (BDNF) correlates with cognitive performance, playing a crucial role in learning, memory, and development of neurocognitive diseases, like dementia and depression. There is currently no data on serum BDNF levels in the context of hyponatremia. Aim: The primary objective of this study was to investigate the effect of hyponatremia correction on serum BDNF levels. Design and MethodsSecondary analysis of a prospective randomized, double-blind, crossover, placebo-controlled trial of 4-week empagliflozin 25mg/d vs placebo treatment in patients with syndrome of inappropriate antidiuresis (SIAD), conducted at the University Hospital Basel, Switzerland, from December 2017 to August 2021. Serum BDNF levels were assessed by quantitative enzyme-linked immunosorbent assay (ELISA). Statistical analyses were performed using R version 4.4.2. Results: A total of fourteen patients were included in the analysis (50% female, median age 72 years [65-77]. At baseline, the median sodium in the empagliflozin group was 131 mmol/l [128-132], which increased to 134 mmol/l [131-136] after treatment (p=0,008). In the placebo group, median sodium was 131mmol/l [130-132] at baseline and remained stable at 131 mmol/l [128-132] after treatment.In the total cohort, an increase in sodium was significantly associated with an increase in BDNF levels (1 mmol/l sodium increase led to a 0.3 ng/ml increase in BDNF levels, p = 0.04), which was more profound after empagliflozin treatment (p=0.004, compared to placebo p=0.3). In the multivariant model the treatment arm was no independent predictor of BDNF change. In patients without an increase in sodium, the median BDNF was 11,4ng/ml [10,2-18] at baseline compared to 10,9 ng/ml [8,7-15,7] after treatment. In patients with an increase in sodium, baseline median BDNF was 12,3 ng/ml [9,6-14,7] and increased to 15,2 ng/ml [11,8-19,3] after the treatment period. No association was observed between Montreal Cognitive Assessment (MoCA) scores and BDNF levels, regardless of treatment group. Conclusion: Our findings indicate that hyponatremia correction is associated with an increase in the serum cognitive marker BDNF, highlighting the importance of hyponatremia correction in cognitive health. Further studies are needed to confirm the role of BDNF upon hyponatremia treatment. References: 1 Refardt et al, JASN, doi.org/10.1681/ASN.2022050623 Presentation: Monday, July 14, 2025
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.003 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".