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Record W4415525024 · doi:10.1101/2025.10.22.25338605

Case Study of Nigeria’s experience scaling up chlorhexidine use in newborns, 2016-2021: analysis of implementation of actions to support scale-up and progress towards institutionalization

2025· preprint· W4415525024 on OpenAlexfundno aff
Jim Ricca, Olayinka Badmus, Bose Adeniran, Femi James, Abdullahi Abdullahi Jatau, Edward Iyemi, Nosa Orobaton, Laura Ghiron, Youngmi Kim, Diwakar Mohan, Regien Biesma

Bibliographic record

VenuemedRxiv · 2025
Typepreprint
Language
FieldNursing
TopicChild Nutrition and Water Access
Canadian institutionsnot available
FundersUniversity of AlbertaBundesministerium für GesundheitJohns Hopkins UniversityBill and Melinda Gates Foundation
KeywordsInstitutionalisationIntervention (counseling)CredibilityFocus groupContext (archaeology)SAFERImplementation researchPublic health

Abstract

fetched live from OpenAlex

ABSTRACT Background Application of chlorhexidine (CHX) to the umbilical stump is an evidence-based intervention to prevent newborn infections. Successful pilot experiences led the Nigeria Federal Ministry of Health (FMoH) to launch a national, five-year scale-up strategy in 2016. In this case study, we analyze the implementation of national and state-level scale-up actions described and mandated in the national strategy and progress toward institutionalizing CHX within the routine health system using the WHO building blocks framework. Methods We conducted a mixed methods case study that consisted of interviews with key informants after the midline of the national strategy; focus groups of well-informed senior stakeholders at midline and endline of the strategy to assess the level of institutionalization achieved and the status of implementation of national-level scale-up actions described in the national strategy; and online surveys of state reproductive health coordinators (SRHCs) at midline and endline about implementation of state-level actions and the extent of international partner support. Results Institutionalization of CHX progressed steadily across all health system building blocks. Most rapid progress was in governance, followed by human resources and supply chain management, with slower progress on the health information system. The building block lagging most was financing, with continued dependence on external funding. Most but not all national-level actions were implemented as planned. There was wide variation in the implementation of state-level actions included in the national plan. Discussion and Conclusion Nigeria has made substantial progress in institutionalizing CHX across the health system building blocks. In terms of implementation of planned state-level scale-up actions, wide variation points to the need for more sustained and coordinated action, and the importance of actively managing this coordination. At national level, as Nigeria continues in the second phase of its scale-up efforts, the FMoH needs to strengthen coordination and financing.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.005
metaresearch head score (Gemma)0.008
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.018
Threshold uncertainty score0.043

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0050.008
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0060.002
Scholarly communication0.0020.002
Open science0.0010.003
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.075
GPT teacher head0.400
Teacher spread0.325 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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