Effect of a GnRH antagonist on the fate of the dominant ovarian follicle and the emergence of the next follicular wave in alpacas
Bibliographic record
Abstract
The objectives of the study were to determine the effects of dose (double vs single) of a GnRH antagonist (Cetrorelix) and follicular status (known status vs random status) on ovarian follicular wave synchrony. In Experiment 1, we tested the hypotheses that treatment of alpacas with two doses of Cetrorelix, will cause 1) regression of the dominant ovarian follicle during both its mid-growing and mid-static phases, and 2) emergence of a new follicular wave at a consistent time after treatment. Ovarian ultrasonography was performed daily and alpacas (n = 7 per group; Day 0 = wave emergence) were given 1.5 mg Cetrorelix acetate im twice at an interval of 24 h starting on Day 5 (mid-growing dominant follicle, D5), Day 10 (mid-static phase, D10) or remained untreated (Control). The mean day of onset of dominant follicle regression was earlier in the D5 group than in the D10 and Control groups (Day 8.7 ± 0.89, 12.9 ± 0.34, 13.6 ± 0.90, respectively; P < 0.001). The largest diameter of dominant follicle was smallest in the D5 group (P = 0.003). The inter-wave interval was shortest in the D5 group (12.7 ± 0.36 days), intermediate in Control (14.6 ± 0.81) and longest in the D10 group (17.7 ± 0.52; P < 0.001). The interval from treatment to wave emergence was similar between D5 and D10 groups (7.7 ± 0.36 days vs 7.7 ± 0.52 days; P > 0.99). In Experiment 2, we tested the hypothesis that a single dose of 1.5 mg Cetrorelix will induce emergence of a new follicular wave synchronously among a group of alpacas on random days of the follicular wave. A new wave emerged 5.3 ± 0.70 days later (n = 15) and was more synchronous (lower variance) than in the pre-treatment control period (Barlett's test p = 0.049, Levene's test p = 0.025). In conclusion, treatment with a single or double dose of 1.5 mg Cetrorelix caused the demise of dominant follicle leading to synchronous emergence of the next follicular wave 5 days (single dose) or 8 days (two doses) later. Results document the potential utility of Cetrorelix in breeding management protocols that enable pre-scheduled, synchronous insemination.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".