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Geometric Features of Ventricular Tachycardia Corridors in Patients With Ischemic Cardiomyopathy

2025· article· en· W4415651930 on OpenAlexaff
Lingyu Xu, Stanislau Hrybouski, Ting‐Wei Ernie Liao, Mirmilad Khoshknab, David J. Callans, Francis E. Marchlinski, Walter R. Witschey, Benoit Desjardins, Saman Nazarian

Bibliographic record

VenueCirculation · 2025
Typearticle
Languageen
FieldMedicine
TopicCardiac Arrhythmias and Treatments
Canadian institutionsUniversité de Montréal
FundersNational Institute of Biomedical Imaging and BioengineeringNational Heart, Lung, and Blood Institute
KeywordsOstiumMagnetic resonance imagingIschemic cardiomyopathyVentricular tachycardiaCardiomyopathyCardiac magnetic resonance imagingGadolinium

Abstract

fetched live from OpenAlex

BACKGROUND: A 3-dimensional hyperboloid model has been proposed to characterize ventricular tachycardia (VT) circuitry. We sought to characterize the geometric features of viable corridors, derived from late gadolinium enhanced cardiovascular magnetic resonance, that participate in VT circuitry in ischemic cardiomyopathy. METHODS: In this retrospective cohort study, we analyzed patients with ischemic cardiomyopathy who underwent cardiovascular magnetic resonance before their first VT ablation between November 2018 and May 2024. Viable corridors traversing infarct tissue on late gadolinium enhanced images were coregistered with VT corridor entrance and exit site coordinates, identified by entrainment/pace mapping. The prevalence of VT corridor geometry (hyperboloid, funnel, or cylinder) and corridor ostium angle, width, length, thickness, volume, and accessibility from chambers accessed during the procedure were measured. RESULTS: The cohort included 46 patients (95.4% male; 68±8 years of age). Of 125 VT exit sites that registered to a corridor ostium among 45 patients, central corridors predominantly exhibited hyperbola geometry (93.6%), with 4.8% exhibiting funnel and 1.6% exhibiting cylinder geometry. Of 11 VT entrance sites that registered to a corridor ostium among 5 patients, all central corridors exhibited hyperbola geometry. The mean angle of corridor ostium at VT exit was significantly larger than the angle of the opposite ostium (mean±SD, 102.8°±34.1° versus 83.2°±29.5°; P < 0.001). CONCLUSIONS: Most VT corridors in patients with ischemic cardiomyopathy, derived from late gadolinium enhanced magnetic resonance images and validated by mapping, were hyperboloid, but funnel and cylinder shapes were also seen. The central hyperbola exhibits a larger opening angle at the exit ostium than the entrance.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.004

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0000.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.004
GPT teacher head0.218
Teacher spread0.214 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes1
Has abstractyes

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