Conservation and Remodeling of Alternative Splicing Landscapes in the Evolution of Panax
Bibliographic record
Abstract
Alternative splicing (AS) is a widely recognized post-transcriptional regulatory mechanism that plays a crucial role in plant evolution and environmental adaptation. In this study, five representative Panax species were systematically analyzed to examine the evolutionary conservation and functional characteristics of AS events. Results revealed an expansion in the number of AS events and associated genes across the Panax species, accompanied by a genome-wide shift in splicing types from a dominance of intron retention (IR) to an increase in exon skipping (ES), alternative donor (A5), and alternative acceptor (A3) events. Splicing preferences were also found to diverge among allotetraploid species, which exhibited more complex AS patterns. The genomic features of IR and ES events, such as GC content and length of the sequence involved in AS, were highly conserved among Panax species of different ploidy levels (diploid vs. allotetraploid). Genes harboring conserved IR events across all five species were identified, and functional annotation indicated that these genes are primarily involved in chromatin modification and RNA splicing-related processes. This study elucidates the dynamic remodeling of AS during the evolution of Panax and provides important insights into the evolutionary adaptive mechanisms of AS in plants.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".