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Record W4415699967 · doi:10.1038/s41598-025-21828-3

Reduced postural stability in men and women aged 55–65 following 14 days of head-down bed rest

2025· article· en· W4415699967 on OpenAlexafffund
Jérémy Rabineau, Roxanne Fournier, Eric T. Hedge, Carmelo Mastrandrea, Richard L. Hughson

Bibliographic record

VenueScientific Reports · 2025
Typearticle
Languageen
FieldMedicine
TopicSpaceflight effects on biology
Canadian institutionsResearch Institute for AgingUniversity of Waterloo
FundersResearch Institute for Aging, University of WaterlooNatural Sciences and Engineering Research Council of CanadaMcGill University Health CentreCanadian Institutes of Health ResearchUniversity of WaterlooCanadian Space AgencyMcGill University
KeywordsBed restDeconditioningPosturographyLower bodyBalance (ability)Center of pressure (fluid mechanics)Centre of pressure

Abstract

fetched live from OpenAlex

Aging and head-down bed rest (HDBR) decrease postural stability. Chances of being bedridden increase with age, but HDBR studies usually focus on young men. Here, we evaluate the impact of HDBR on postural stability among late middle-aged individuals. Twenty-two healthy participants (55-65 years old, 11 women) were exposed to 14-day HDBR. Eleven participants performed daily exercise. Static posturography data were collected before, 5 h after, and 4 weeks after HDBR. No time×group or time×sex effects were observed, but women had lower postural stability. With eyes open, the root mean square of the center of pressure was larger immediately after HDBR only in the medio-lateral axis (median [interquartile range]: +53% [+ 15%; +129%], p = 0.002). The mean velocity was increased on both axes (+ 20% [+ 8%; +46%] for medio-lateral and + 19% [+ 13%; +36%] for antero-posterior, both p < 0.001). The complexity features and the critical time were left unchanged. The effects of HDBR were more visible in the eyes open condition and the deconditioning was reversible after four weeks. 14-day HDBR decreased postural stability in individuals aged 55-65, with no impact of the chosen countermeasure. While the deconditioning was equivalent to two decades of aging for some features, additional research is required to determine whether age was an aggravating factor.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.006
Threshold uncertainty score0.011

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.015
GPT teacher head0.299
Teacher spread0.285 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

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