Overnight deep inspiration patterns in obstructive sleep apnea patients with and without asthma
Bibliographic record
Abstract
Asthma and obstructive sleep apnea (OSA) often co-occur, exacerbating respiratory difficulties and altering airway physiology during sleep. Respiratory obstructions in OSA usually terminate with deep inspiration, and in asthma, deep inspiration may function as a bronchodilator or induce bronchoconstriction. This study investigated deep inspiration patterns using polysomnography data from 202 OSA patients (Apnea-Hypopnea Index (AHI) > 5) in the Sleep Heart Health Study, including asthma patients and matched controls. Airflow signals were used to calculate the average amplitude of three post-event deep breaths (PEDB), as overshoots usually peak within these breaths. PEDB curves were compared within and between groups, each including 68 mild, 19 moderate, and 14 severe OSA cases (AHI > 30). In severe OSA, mean PEDB increased from the first to last sleep quartile in controls (p < 0.05) but showed no change in those with asthma (p > 0.05). PEDB values were higher in controls than in asthma patients with moderate and severe OSA. Reduced PEDB intensity in severe OSA with asthma suggests impaired bronchodilator effects of deep inspirations, possibly from chronic inflammation and fluid shifts. These findings enhance understanding of asthma-OSA interactions and the potential role of deep inspirations in mitigating overnight narrowing in lower airways.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".