Abstract 4360616: Cardiovascular magnetic resonance imaging estimation of diffuse myocardial and hepatic fibrosis late after tetralogy of Fallot repair
Bibliographic record
Abstract
Background: Cardiovascular magnetic resonance imaging (CMR) can estimate diffuse myocardial fibrosis using extracellular volume fraction (ECV) quantification. Objectives: This study aimed to explore associations between and prognostic value of myocardial and hepatic fibrosis after tetralogy of Fallot repair (rTOF). Methods: Adults with rTOF were prospectively enrolled along with healthy controls. Patients were categorized by hemodynamic load (pulmonary stenosis and/or pulmonary regurgitation). Available clinical data were recorded at study entry. Myocardial and hepatic ECV were calculated from pre/post-contrast T1 maps. The primary outcome was a composite of death, resuscitated sudden death, sustained ventricular tachycardia (VT) or VT requiring invasive therapy, and/or heart failure requiring hospital admission. Multivariable modelling was used to examine the association between CMR measures and adverse cardiovascular events. Results: We studied n=181 patients (56% male; median age 33 years [IQR 26–47]) and n=20 age/sex-matched controls. Hepatic and myocardial fibrosis measures were correlated (r=0.031, p<0.001). Diffuse hepatic fibrosis was higher in rTOF patients as compared with controls (586±69 versus 531±75 msec, p=0.006) with statistically significant differences between hemodynamic load type (p=0.04). Right ventricular (RV) native T1 in rTOF was increased as compared with controls (1081±76 versus 997±743 msec, p<0.001) with a trend towards significant differences when stratified by hemodynamic load (p=0.09). Late gadolinium enhancement (LGE) was seen in the RV in 46% (n=83) and in the left ventricle (LV) in 37% (n=66). At median follow-up 2.1 years (IQR 0.7-2.7), the composite outcome occurred in 9% (n=17). Independent predictors of adverse cardiovascular events on multivariable models, adjusted for age and sex, were RV end-systolic volume (HR 1.43, 95%CI 1.09-1.99, p=0.02), RV native T1 (HR 1.15, 95%CI 1.07-1.25, p<0.01) and LV LGE (HR 3.15, 95%CI 1.06-10.13, p<0.04); hepatic fibrosis was not associated with outcome. Conclusion: In rTOF, myocardial and hepatic fibrosis were modestly correlated. As compared with controls, myocardial and hepatic fibrosis was increased in rTOF. Diffuse myocardial fibrosis in the RV (native T1) and replacement fibrosis in the LV (LGE) were independently associated with cardiovascular outcomes, although hepatic fibrosis was not. These findings should be validated in larger populations with longer follow-up.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".