Abstract 4368055: Postprandial Hypotension and Blood Pressure Variability in Type 2 Diabetes
Bibliographic record
Abstract
Background: Postprandial hypotension (PPH) is a frequent but under-recognized hemodynamic disturbance in patients with type 2 diabetes mellitus (T2DM). This study aimed to evaluate the prevalence and characteristics of PPH and examine its association with blood pressure variability (BPV) and clinical parameters. Methods: We enrolled 121 T2DM patients (mean age 61.1±11.2 years; 50.4% female) who underwent 24-hour ambulatory blood pressure monitoring (ABPM) with annotation of meal times. PPH was defined as a post-meal systolic BP drop ≥20 mmHg. BPV indices included systolic/diastolic standard deviation (SD), coefficient of variation, dipping pattern, and morning surge. Additional analyses were performed in patients with available data for arterial stiffness (pulse wave velocity [PWV], ankle-brachial index [ABI]) and cognitive function (Montreal Cognitive Assessment [MOCA]). Results: PPH was observed in 57 patients (47.1%). The mean postprandial systolic BP drop was 11.6±10.9 mmHg, with the largest decrease noted after dinner. Among those with PPH, 35 patients (61.4%) exhibited abnormal dipping patterns: non-dipper (28.1%), reverse dipper (15.8%), and extreme dipper (17.5%). Morning BP surge was more frequent in the PPH group (60.0% vs 39.3%, p=0.046). Daytime systolic BPV was significantly higher in PPH patients (18.2±5.9 vs 15.6±4.2 mmHg, p=0.027), while nocturnal BPV and diastolic BPV showed no significant differences. The degree of postprandial BP drop showed no significant correlation with nighttime dipping percent or other BPV indices. In subgroup analyses (PWV: n=101; MOCA: n=90), no significant associations were found between PPH or BPV and arterial stiffness or cognitive function parameters (all p>0.1). Conclusion: PPH is prevalent in T2DM patients and is associated with specific BPV patterns such as attenuated dipping and increased morning surge. However, the extent of BP drop is unrelated to nighttime dipping or other BPV measures and appears independent of arterial stiffness and cognitive status. These findings support the potential clinical significance of BPV-PPH interaction and warrant further longitudinal research.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".