The Velvet Complex Is Essential for Sclerotia Formation and Virulence in Sclerotinia sclerotiorum
Bibliographic record
Abstract
Sclerotinia sclerotiorum is a devastating soilborne fungal pathogen that causes Sclerotinia stem rot in many economically important crops. It forms sclerotia, resilient dormant structures that can persist in soil for years. Understanding the molecular mechanism of sclerotia formation is crucial for developing effective control strategies, but only a limited number of signaling components have been uncovered in this process. Through independent forward genetic screens, we identified SsLae1 and SsVel1, two core components of the conserved fungal velvet complex, as essential regulators of sclerotia formation and virulence in S. sclerotiorum. Disruption of either gene abolished sclerotia formation, impaired compound appressorium development, and significantly reduced virulence. Further RNA-seq analysis using the Ssvel1 mutant revealed widespread downregulation of known developmental and virulence regulators. Collectively, these findings establish the velvet complex as a master regulator for both sclerotia development and virulence in S. sclerotiorum.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".