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Record W4415848646 · doi:10.1002/gin2.70047

Understanding the Determinants That Influence the Development and Implementation of Evidence‐Based Practice Guidelines During Health Emergencies: An Exploratory Sequential Mixed‐Methods Study Protocol

2025· article· en· W4415848646 on OpenAlexafffund
Gonzalo Bravo‐Soto, Shelly‐Anne Li, Gordon Guyatt, Nancy Santesso, Susan M. Jack, Thomas Agoritsas, François Lamontagne, John N. Lavis, Reem A. Mustafa, Bram Rochwerg, Wojtek Wiercioch, Linan Zeng, Ludovic Revéiz, Romina Brignardello‐Petersen

Bibliographic record

VenueClinical and Public Health Guidelines · 2025
Typearticle
Languageen
FieldHealth Professions
TopicHealth Policy Implementation Science
Canadian institutionsUniversité de SherbrookeMcMaster UniversityMcMaster University Medical CentreUniversity Health NetworkImpact
FundersCanadian Institutes of Health Research
KeywordsGuidelineProtocol (science)Health careExploratory researchData collectionSample (material)Process (computing)Qualitative research

Abstract

fetched live from OpenAlex

ABSTRACT Introduction The COVID‐19 pandemic highlighted the crucial role of evidence‐based practice guidelines (EBPGs) in healthcare systems. Reliable and timely guidelines are essential in health emergencies. This study aims to identify and comprehensively understand the determinants that influence the development and implementation of EBPGs during health emergencies from the perspective of guideline developers and implementers. In this article, we describe the study protocol. Methodology We will conduct an exploratory sequential mixed‐methods study composed of four phases: (I) a qualitative descriptive study to document the experiences of guideline developers and implementers and use this data to generate a list of determinants that influence the development and implementation of EBPG; (II) exploratory integration for survey development and validation using the data of phase I; (III) cross‐sectional study to administer the survey to a large sample and estimate the frequency and perceived impact of those determinants; (IV) interpretation of the results: a combination of qualitative and quantitative findings through the narrative description and joint displays to generate a comprehensive understanding of those determinants. We will explore if results vary across subgroups of interest (participants' roles, gender, and type of organization). We will include people worldwide from five groups participating in an EBPG development and implementation process during the pandemic. Discussion This study will provide insights into the determinants that influence the development and implementation of EBPGs during health emergencies. Its potential impact includes improving future health emergency preparedness, addressing equity gaps, and enhancing guideline development and implementation.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.097
metaresearch head score (Gemma)0.034
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Science and technology studies
Consensus categoriesMetaresearch
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.473
Threshold uncertainty score0.997

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0970.034
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.001
Science and technology studies0.0040.000
Scholarly communication0.0000.001
Open science0.0010.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.951
GPT teacher head0.796
Teacher spread0.155 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; both teacher heads agree on what is shown here.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

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